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HLCL-61 is also effective in promoting apoptosis in MV4-11 and THP-1 cells after 48 h
2146/ajhp120602
conscious rats
the WIN-55212-2 mesylate (0
It binds CBP and p300 bromodomains directly
Temsirolimus dzin HLCL-61 is also effective inTemsirolimus is an ester analog of rapamycin. Temsirolimus binds to and inhibits the mammalian target of rapamycin (mTOR), resulting in decreased expression of mRNAs necessary for cell cycle progression and arresting cells in the G1 phase of the cell cycle. mTOR is a serine threonine kinase which plays a role in the PI3K AKT pathway that is upregulated in some tumors. Temsirolimus (CCI 779) is an intravenous drug for the treatment of renal cell
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